The auris interna.Restorative process in guinea pig acoustic trauma model.

Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig

Animal models of tinnitus allow us to study the relationship between changes in neural activity and the tinnitus percept. Here, guinea pigs were subjected to unilateral noise trauma and tested behaviourally for tinnitus 8 weeks later. By comparing animals with tinnitus with those without, all of which were noise-exposed, we were able to identify changes unique to the tinnitus group. Three physi...

Approach of the Intracochlear Acoustic Reflex in the Guinea Pig

Acoustic stimulation increases phosphoinositide breakdown in the guinea pig cochlea.

The effect of sound stimulation on phosphoinositide turnover was investigated in the inner ear of the guinea pig. The perilymphatic spaces of the cochlea were perfused with [(32)P]orthophosphate ((32)P(i)) and labeled lipids analyzed in the tissues of the lateral wall of the cochlea (stria vascularis and spiral ligament) and the basilar membrane (organ of Corti). Consistent with previous result...

Acoustic stimulation promotes DNA fragmentation in the Guinea pig cochlea.

Apoptosis can be described as programmed cell death. Apoptosis regulates cell turnover and is involved in various pathological conditions. The characteristic features of apoptosis are shrinkage of the cell body, chromatin condensation, and nucleic acid fragmentation. During apoptosis, double-stranded DNA is broken down into single-stranded DNA (ssDNA) by proteases. Acoustic trauma is commonly e...

Some observations on the feeding of the guinea pig